Saturday, March 21, 2020

VIRAL LOAD MANAGEMENT


Never let a serious crisis go to waste. ~ Rahm Emmanuel 

Politicians have finally decided to take demonstrative actions to reduce the spread of the coronavirus and reassure the public that they really don’t need to wipe out all the available packages of toilet paper from local stores. Unsurprisingly, most of these actions to date have been initiated by local and state governments. However, Dr. Anthony Fauci has further cemented his role as America’s 79-year old patron saint of rational, informed virus dialogue. Thank you, thank you Dr. Fauci.
On March 19 California Governor Gavin Newsom adopted the local SF Bay Area counties’ recently-enacted Shelter-in-Place – ShiP – rules (aka, everyone stay at home) by ordering all Californians to board the ShiP until further notice. Welcome to the ShiP, designed to manage our rising viral load.
According to the letter sent by Governor Newsom to President Trump, the governor justified his state-wide order by stating, “We believe the virus will impact about 56% of California’s population – 25.5 million people – within the next eight weeks.” This estimated 56% infection rate is apparently based on projections from Johns Hopkins University. It’s been a sellers’ market for epidemiologists and their models that have spread far and wide. The more chilling these models’ predictions are, the more media-notice they get.
Here’s why the governor’s projections are fugazzi[1] math. California’s current population is 39.94 million people. His statement that 25.5 million people represent 56% of the population means his state population has to be 45.54 million [45.54 = 25.5/0.56], which it’s clearly not. To make his math work, he’s overestimating California’s population by 15%. Oh, well. His heart is in the right place.
Also extreme is his assumed 56% infection rate. This is a gigantic percentage of people who will have been infected (assuming the governor’s fuzzy word, “impact” means infected) by the coronavirus in eight weeks. For comparison, Italy is dealing with its own significant viral threat that’s several weeks ahead of California’s. Italy now has 41,021 cases of covid-19, the largest in Europe, out of a total population of 60.48 million people. Its infection rate is thus 0.07%. As of March 21, the New York Times shows California has 1,261 coronavirus cases and 23 deaths, which works out to a case fatality rate of 1.8%. Cases will certainly surge, as epidemiologically expected, with more testing finally getting done and as the virus continues its sweep, but having over one-half of my fellow Californians be infected has not been expected.
As threatening as Italy’s infection rate is, it’s worlds apart from Gov. Newsom’s projected 56% rate. However, there is virtually no downside for politicians not amplifying the potential threat to their constituents; even if a worst, worst-case epidemiological model result is used like the governor probably did. He understandably wants attention and fiscal support from the federal government, overly-giant numbers probably help. Even though any projections, like those from Johns Hopkins, remain based on completely preliminary, ever-changing input values for infection and case fatality rates. However, Gov. Newsom’s dramatic prediction for viral infections in California got #45’s commitment to send the USNS Mercy Hospital Ship to the Port of Los Angeles. Alas, #45’s promise wasn’t to last, like too many others. Later, the US Navy said the Mercy would instead be steaming to Seattle, the initial US epicenter of the coronavirus pandemic.
The Governor’s 56% infection rate together with a fatality rate of 3% (similar to China, Iran and Italy) would produce 5.55 million possible deaths in the US from covid-19. That is over four times the deaths from summing the fatalities of both heart disease and cancer, the two most lethal diseases in the US.
This series of ever-escalating, extreme epidemiological projections may provoke stronger policy actions that can begin to manage the viral load on our healthcare system.
For politicians, ever-stricter interventions are designed in no small part to demonstrate they care, really care, about their constituents’ well-being, whether or not such rules and orders are truly effective. A fine example of this is the federal Treasury Department’s possibly postponing the due date for annual tax form submission from April 15 to July 15. This proposal seems fairly vacuous; after all, for the expanded millions of us who now live under SHiP orders – and it’s only a matter of time that we all will be – won’t we have more time to fill out our 1040EZ’s by April 15? But Secretary Mnuchin’s postponement perhaps shows he does care about the stress of filing your tax form in just 3½  weeks, while you’re doing nothing else.
Media criticism has focused the fact that US hospitals are “thoroughly unprepared” to deal with this viral crisis, citing the US’s rather low hospital beds/1000 people statistic. Such criticism implies or explicitly mentions that if we miraculously already had a publicly-funded, universal healthcare system – say along the lines of Medicare-for-All that Bernie Sanders (remember him?) has proposed – everything would better.  
That’s very unlikely. The US hospital beds/1000 people statistic is 2.89; the UK’s statistic (home of the publicly-funded National Health Service, NHS) is 2.76, according to OECD data. Both US healthcare and the NHS, two nations with two very different systems, have apparently under-invested in medical capacity. But every nation’s healthcare system has inadequate capacity to deal with a novel coronavirus pandemic that no one’s built up immunity to.
My reaction to such criticism is at best a large simplification with a very pricy solution. If our healthcare sector were built to satisfy every unforeseen peak-demand surge, like covid-19, and thus have existing physical infrastructure (e.g., hospitals, beds, medical equipment) and more importantly additional numbers of well-trained medical staff (doctors, nurses, administrators) to deal with every unanticipated peak demand, we citizens would be paying far more for healthcare every month, whether a peak happens or not. I doubt whether many people or politicians would be willing to have their regular healthcare costs or taxes increase to build for such peaks that would only rarely happen. If you build to meet any unforeseen peak, you pay for that capability each and every day.
Healthcare systems are managed to deal with expected variations in required demand, through disaster preparedness plans, contingent staffing and supply-chain tractability. Satisfying sizeable, unexpected peak medical demand would require large numbers of extra Emergency Rooms, ICUs, beds, equipment, nurses and doctors to be already available in place. No real instant-on extra hospital capacity or nurses or doctors are realistically possible, aside from temporary structures or Clinics-in-a-Can. Training nurses and doctors takes years, not weeks. Having such medical healthcare resources standing idly by only for infrequent extreme peak surges would be a significantly expense, all the time. The complaint about insufficient extreme peak medical capacity is real. Its solution would be steep for the healthcare system, no matter what its structure or ownership. That’s the logic of reducing peak medical demand via “flattening the curve.”
Flatten the curve has rapidly become policy makers' go-to goal for managing and surviving the coronavirus’ spread, and is hypothetically illustrated in the chart below.  
Flattening the Curve

A concern I have with this curve flattening is that the public’s general acceptance of the goal does not include much understanding of one consequence. Specifically, as policy and personal actions hopefully, eventually flatten the curve, people will become infected over a much-extended time period, as shown above. Thus, people and hospitals will have to deal with coronavirus cases during a far more protracted period. Will that be ok with everyone? Everybody is now for flattening the curve, are they also for extending the viral distress?
The coronavirus pandemic’s timeline is very distinct from the many financial crises we’ve weathered. The virus’s time period is sort of reversed: it is unclear what will happen in the coming several months, but reasonably certain (hopefully) that within twelve months its menace will have subsided. This world-wide health emergency is unlike the economic crisis of 2007-09, where the government was certain what it had to do in the immediate time, but uncertain about the longer-term issues would be.
Speaking of economic crises, the coronavirus’ consequent economic maelstrom is now growing ever-larger. As I mentioned above about the propensity of seemingly worst-worst case projections to dominate headlines, the same also goes with regard to the imminent “coronavirus recession.” One economics professor cogently characterized our upcoming recession as: This will probably be the world’s first recession that starts in the service sector, not in manufacturing.
JPMorgan Chase now estimates that the economy could decrease by 14% between April and June, the biggest contraction since post-WWII era. Goldman Sachs estimates 2.25 million people filed for unemployment this week, nearly a ten-times increase from a week ago. That estimate was before the White House demanded that state employment agencies not publicly provide information regarding unemployment claims.
Goldman Sachs (GS) also projected 0% GDP growth in the first quarter of this year and a 5% contraction in the second quarter. It estimated that we will lose 3 million jobs by summer. But then on Wednesday, JP Morgan saw GS and raised them in forecasting that the second quarter contraction would be a stunning 14% — worse than the depth of the Great Recession. This forecast could translate to 7.5 million jobs lost by the summer. Others are predicting that the drop in payrolls for April alone could be as high as 5 million.
Can we manage the coronavirus’ expansion and mitigate economic damage by flattening the curve with enough of us staying in our residences for an extended period? If we unswervingly practice staying in our dwellings, washing our hands semi-continuously, maintain 6-ft personal distancing, stop dancing on any beaches and stop tippling in all bars and restaurants, time will tell. Here’s hoping, really hoping.





[1] Fugazi is a slang word which refers to something that is fake or damaged beyond repair


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